Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8766468 | 0.96 | PKM (0.41) | HTTPKMLMNANPC1RAB9A | |
| SCHEMBL8766432 | 0.83 | HTT (0.40) | HTTLMNANPC1RAB9AADRA1D | |
| SCHEMBL8772451 | 0.82 | LMNA (0.40) | HTTPKMLMNAALDH1A1MEN1 | |
| SCHEMBL8767314 | 0.76 | PKM (0.38) | HTTPKMLMNAADRA1DADRA1A | |
| SCHEMBL8767413 | 0.76 | PKM (0.37) | HTTPKMLMNAADRA1DADRA1A | |
| SCHEMBL8767579 | 0.74 | PKM (0.40) | HTTPKMLMNAADRA1DADRA1A | |
| SCHEMBL8766856 | 0.72 | HTT (0.39) | HTTLMNAADRA1DADRA1AADRA1B | |
| SCHEMBL8766787 | 0.71 | HTT (0.39) | HTTLMNANPC1ADRA1DADRA1A | |
| SCHEMBL9109873 | 0.71 | CYSLTR2 (0.47) | — | |
| SCHEMBL9109323 | 0.71 | CYSLTR2 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | disclosed |