SCHEMBL8768200

SCHEMBL8768200

COc1cc(C=NN=Cc2ccccc2)cc(OC)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM5 P08912 1/20 0.67
LMNA P02545 1/20 0.58
L3MBTL1 Q9Y468 1/20 0.58
MAPT P10636 3/20 0.51
KMT2A Q03164 3/20 0.51
USP2 O75604 2/20 0.51
KDM4E B2RXH2 1/20 0.51
MEN1 O00255 1/20 0.51
ALDH1A1 P00352 1/20 0.51
TP53 P04637 1/20 0.51
CYP3A4 P08684 1/20 0.51
HPGD P15428 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
TRPV1 Q8NER1 1/20 0.51
HSD17B10 Q99714 1/20 0.51
TAAR1 Q96RJ0 1/20 0.50
CYP1B1 Q16678 3/20 0.48
CYP1A1 P04798 2/20 0.48
ABL1 P00519 3/20 0.47
BCR P11274 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10706017 0.88 CHRM5 (0.63) CHRM5MAPTKMT2AKDM4EMEN1
SCHEMBL7616145 0.84 TRPA1 (0.67) CHRM5LMNAL3MBTL1KMT2AMEN1
SCHEMBL1654602 0.80 CHRM5 (1.00) CHRM5KDM4ECYP3A4TAAR1NQO2
SCHEMBL14832122 0.79 ALDH1A1 (0.52) CHRM5MAPTKMT2AUSP2KDM4E
SCHEMBL14832121 0.79 ALDH1A1 (0.52) CHRM5MAPTKMT2AUSP2KDM4E
SCHEMBL22198166 0.79 CHRM5 (0.50) CHRM5MAPTKMT2AKDM4EMEN1
SCHEMBL22198244 0.79 EGFR (0.51) CHRM5L3MBTL1MAPTKMT2AKDM4E
3,5-O-Dimethylpinosylvin SCHEMBL918727 0.78 KDM4E (0.79) MAPTKMT2AUSP2KDM4EMEN1
3,5-O-Dimethylpinosylvin SCHEMBL9419809 0.78 KDM4E (0.79) MAPTKMT2AUSP2KDM4EMEN1
SCHEMBL11810449 0.78 USP2 (0.56) CHRM5MAPTKMT2AUSP2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0792476-A1 PHOTOTHERMOGRAPHIC ELEMENT WITH REDUCED WOODGRAIN INTERFERENCE PATTERNS Imation Corp. (US) 1997-09-03 EP disclosed
WO-1996015479-A1 PHOTOTHERMOGRAPHIC ELEMENT WITH REDUCED WOODGRAIN INTERFERENCE PATTERNS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1996-05-23 WO disclosed