Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11757932 | 0.79 | L3MBTL1 (0.43) | CASP1HSD17B10L3MBTL1CA2CA12 | |
| SCHEMBL636001 | 0.78 | VCP (0.43) | CASP1HSD17B10L3MBTL1ACHETSHR | |
| SCHEMBL11164918 | 0.75 | TSHR (0.47) | CASP1HSD17B10L3MBTL1CA2CA12 | |
| SCHEMBL29436012 | 0.74 | CA2 (0.50) | CASP1HSD17B10CA2CA12CA1 | |
| SCHEMBL179467 | 0.74 | CA2 (0.50) | CASP1HSD17B10CA2CA12CA1 | |
| SCHEMBL27784134 | 0.74 | TSHR (0.46) | L3MBTL1CA2CA12CA1CA7 | |
| SCHEMBL14660462 | 0.72 | CA2 (0.48) | CASP1HSD17B10L3MBTL1CA2CA12 | |
| SCHEMBL11063020 | 0.72 | ALDH1A1 (0.47) | HSD17B10L3MBTL1CA2CA12CA1 | |
| SCHEMBL601662 | 0.72 | TSHR (0.52) | CASP1HSD17B10L3MBTL1CA2CA12 | |
| SCHEMBL9620 | 0.72 | ALDH1A1 (0.44) | CA2CA1CYP3A4CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4416871-A | Inhibition by peptides of tolerance to and physical dependence on morphine | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1983-11-22 | — | — | US | claimed |
| US-RE30496-E | Tripeptide derivatives with central nervous system activity and preparation thereof | AYERST, MCKENNA & HARRISON, LTD. (CA) | 1981-01-27 | — | — | US | claimed |
| EP-0016136-A1 | INHIBITION BY PEPTIDES OF TOLERANCE TO AND DEPENDENCE ON MORPHINE | University of Illinois Foundation (US) | 1980-10-01 | — | — | EP | claimed |
| WO-1980000216-A1 | INHIBITION BY PEPTIDES OF TOLERANCE TO AND DEPENDENCE ON MORPHINE | UNIV ILLINOIS (US) | 1980-02-21 | — | — | WO | claimed |
| US-4018912-A | Tripeptide derivatives with central nervous system activity and preparation thereof | AYERST MCKENNA AND HARRISON LTD. (CA) | 1977-04-19 | — | — | US | claimed |
| EP-0792283-A1 | SYNTHESIS OF PEPTIDE NUCLEIC ACIDS (PNAs) AND ANALOGUES VIA SUBMONOMER APPROACH | CHIRON CORPORATION (US) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015143-A1 | SYNTHESIS OF PEPTIDE NUCLEIC ACIDS (PNAs) AND ANALOGUES VIA SUBMONOMER APPROACH | CHIRON CORPORATION (US) | 1996-05-23 | — | — | WO | disclosed |
| US-RE30496-E | Tripeptide derivatives with central nervous system activity and preparation thereof | AYERST, MCKENNA & HARRISON, LTD. (CA) | 1981-01-27 | — | — | US | disclosed |
| US-4018912-A | Tripeptide derivatives with central nervous system activity and preparation thereof | AYERST MCKENNA AND HARRISON LTD. (CA) | 1977-04-19 | — | — | US | disclosed |