Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8984047 | 0.90 | FLT1 (0.40) | KDM4ETSHRHPGDHSD17B10FLT1 | |
| SCHEMBL30804592 | 0.80 | KDM4E (0.55) | KDM4ETSHRHPGDHSD17B10FLT1 | |
| SCHEMBL30804597 | 0.80 | KDM4E (0.55) | KDM4ETSHRHPGDHSD17B10FLT1 | |
| SCHEMBL395135 | 0.80 | KDM4E (0.55) | KDM4ETSHRHPGDHSD17B10FLT1 | |
| SCHEMBL9874246 | 0.76 | TAS1R3 (0.41) | KDM4ETSHRHPGDHSD17B10FLT1 | |
| SCHEMBL8984088 | 0.74 | MT-CO2 (0.45) | KDM4ETSHRHPGDHSD17B10FLT1 | |
| Hydrochloric Acid SCHEMBL9875354 | 0.73 | MT-CO2 (0.44) | KDM4ETSHRHPGDHSD17B10FLT1 | |
| SCHEMBL4188631 | 0.72 | AURKA (0.59) | KDM4ETSHRHPGDHSD17B10FLT1 | |
| SCHEMBL3286845 | 0.69 | KDM4E (0.46) | KDM4ETSHRHPGDHSD17B10FLT1 | |
| SCHEMBL22497632 | 0.69 | KDM4E (0.50) | KDM4ETSHRHPGDHSD17B10FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0789690-A1 | N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-08-20 | — | — | EP | disclosed |
| WO-1996014300-A1 | N-ARYL AND N-HETEROARYL-1,2-DIAMINOCYCLOBUTENE-3,4-DIONES WITH SMOOTH MUSCLE RELAXING ACTIVITIES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-05-17 | — | — | WO | disclosed |