Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8769018 | 0.90 | KDM4E (0.43) | FLT1FLT4KDRKDM4ETSHR | |
| SCHEMBL8984088 | 0.75 | MT-CO2 (0.45) | FLT1FLT4KDRKDM4ETSHR | |
| SCHEMBL30804597 | 0.74 | KDM4E (0.55) | FLT1FLT4KDRKDM4ETSHR | |
| SCHEMBL30804592 | 0.74 | KDM4E (0.55) | FLT1FLT4KDRKDM4ETSHR | |
| SCHEMBL395135 | 0.74 | KDM4E (0.55) | FLT1FLT4KDRKDM4ETSHR | |
| Hydrochloric Acid SCHEMBL9875354 | 0.74 | MT-CO2 (0.44) | FLT1FLT4KDRKDM4ETSHR | |
| SCHEMBL30050529 | 0.73 | C1R (0.34) | — | |
| SCHEMBL24035066 | 0.72 | NISCH (0.44) | KDM4ETSHRGAAKMT2AL3MBTL1 | |
| SCHEMBL9874246 | 0.71 | TAS1R3 (0.41) | FLT1FLT4KDRKDM4ETSHR | |
| SCHEMBL29266627 | 0.70 | CTSS (0.37) | KDRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449172-B1 | A method of reducing a carbonyl containing acridine | HOECHST ROUSSEL PHARMA (US) | 1996-06-05 | — | — | EP | disclosed |
| EP-0581194-A1 | A process for the preparation of enamines in aqueous media | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-02-02 | — | — | EP | disclosed |
| US-5247091-A | Preparation of enamines in aqueous media | HOECHST CELANESE CORPORATION (US) | 1993-09-21 | — | — | US | disclosed |
| EP-0449172-A1 | A method of reducing a carbonyl containing acridine | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-10-02 | — | — | EP | disclosed |
| US-5053513-A | Catalytic hydrogenation using noble metal catalyst, lithium hydroxide, solvent | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-10-01 | — | — | US | disclosed |