SCHEMBL8769343

SCHEMBL8769343

O=C1CC(N2CCNCC2)C(=O)N1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.56
TDP1 Q9NUW8 2/20 0.56
MEN1 O00255 1/20 0.56
APEX1 P27695 1/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
RAB9A P51151 1/20 0.51
ALDH1A1 P00352 4/20 0.49
LMNA P02545 1/20 0.49
HTT P42858 1/20 0.49
KDM4E B2RXH2 1/20 0.44
MAP3K14 Q99558 1/20 0.39
CRBN Q96SW2 5/20 0.38
DDB1 Q16531 3/20 0.37
HPGD P15428 1/20 0.36
MAPK1 P28482 1/20 0.36
CHRM2 P08172 1/20 0.35
OPRM1 P35372 1/20 0.35
IKZF3 Q9UKT9 1/20 0.35
CYP1A2 P05177 1/20 0.35
TSHR P16473 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29290644 0.82 KMT2A (0.57) KMT2ATDP1MEN1APEX1L3MBTL1
SCHEMBL20812035 0.81 CRBN (0.54) KMT2ATDP1MEN1APEX1L3MBTL1
Water SCHEMBL28335951 0.79 CRBN (0.53) KMT2ATDP1MEN1APEX1L3MBTL1
Hydrochloric Acid SCHEMBL19585786 0.79 CRBN (0.53) KMT2ATDP1MEN1APEX1L3MBTL1
SCHEMBL22960861 0.78 KMT2A (0.54) KMT2ATDP1MEN1APEX1L3MBTL1
SCHEMBL31073664 0.77 KMT2A (0.61) KMT2ATDP1MEN1APEX1L3MBTL1
SCHEMBL2212446 0.77 DRD2 (0.60) RAB9AALDH1A1LMNAHTTKDM4E
SCHEMBL16610511 0.76 ALDH1A1 (0.47) KMT2ATDP1MEN1APEX1L3MBTL1
SCHEMBL31690364 0.75 CRBN (0.39) KMT2ATDP1MEN1APEX1L3MBTL1
SCHEMBL30830490 0.74 CRBN (0.48) KMT2ATDP1MEN1APEX1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0451380-B2 Succinimide compositions ETHYL PETROLEUM ADDITIVES LTD (GB) 1997-07-30 EP disclosed
US-5171466-A From polyisobutenyl succinic anhydride and polyalkylene amines followed by phosphorylation or bononation; dispersants for lubricating oils ETHYL PETROLEUM ADDITIVES LIMITED (GB) 1992-12-15 US disclosed
EP-0451380-A1 Succinimide compositions ETHYL PETROLEUM ADDITIVES LIMITED (GB) 1991-10-16 EP disclosed