Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 4/20 | 0.66 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.58 |
| ▸ | REN | P00797 | 2/20 | 0.54 |
| ▸ | CTSL | P07711 | 3/20 | 0.53 |
| ▸ | CTSS | P25774 | 2/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | ECE1 | P42892 | 2/20 | 0.50 |
| ▸ | CTSB | P07858 | 2/20 | 0.50 |
| ▸ | CTSK | P43235 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | MME | P08473 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425592 | 0.92 | CTSD (0.67) | CTSDTRPM8RENCTSLCTSS | |
| SCHEMBL6445103 | 0.90 | CTSD (0.76) | CTSDTRPM8RENCTSLCTSS | |
| SCHEMBL6132144 | 0.90 | CTSD (0.76) | CTSDTRPM8RENCTSLCTSS | |
| SCHEMBL6449641 | 0.90 | CTSD (0.76) | CTSDTRPM8RENCTSLCTSS | |
| SCHEMBL6446151 | 0.90 | CTSD (0.76) | CTSDTRPM8RENCTSLCTSS | |
| SCHEMBL6446780 | 0.90 | CTSD (0.76) | CTSDTRPM8RENCTSLCTSS | |
| SCHEMBL9232828 | 0.90 | CTSD (0.76) | CTSDTRPM8RENCTSLCTSS | |
| SCHEMBL9740721 | 0.90 | CTSD (0.76) | CTSDTRPM8RENCTSLCTSS | |
| SCHEMBL8163494 | 0.88 | TRPM8 (0.69) | CTSDTRPM8CTSLCTSSCTSB | |
| SCHEMBL7418811 | 0.88 | TRPM8 (0.69) | CTSDTRPM8CTSLCTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793673-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN L INHIBITOR | Takeda Chemical Industries, Ltd. (JP) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016079-A2 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN L INHIBITOR | TAKEDA CHEMICAL INDUSTRIES, LTD (JP) | 1996-05-30 | — | — | WO | disclosed |