Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA3 | P07451 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA6 | P23280 | 1/20 | 0.55 |
| ▸ | CA5A | P35218 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CASP3 | P42574 | 2/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14947756 | 0.85 | POLB (0.57) | MMP8GAACA12CA1CA2 | |
| SCHEMBL20804412 | 0.85 | POLB (0.57) | MMP8GAACA12CA1CA2 | |
| SCHEMBL2600864 | 0.85 | MMP8 (0.58) | MMP8MAPTCA12CA1CA2 | |
| SCHEMBL2600863 | 0.83 | CA12 (0.74) | MMP8GAAMAPTCA12CA1 | |
| SCHEMBL9275432 | 0.79 | TLR2 (0.56) | MMP8CA12CA1CA2CA3 | |
| SCHEMBL7034199 | 0.79 | CTSL (0.53) | MMP8CA12CA1CA2CA3 | |
| SCHEMBL8358645 | 0.79 | TLR2 (0.56) | MMP8CA12CA1CA2CA3 | |
| SCHEMBL9617186 | 0.78 | MMP8 (0.53) | MMP8GAAMAPTCA12CA1 | |
| SCHEMBL21206863 | 0.78 | KMT2A (0.61) | MMP8MAPTKMT2AMMESLC1A2 | |
| SCHEMBL7508357 | 0.78 | GAA (0.53) | MMP8GAAMAPTCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0793673-A1 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN L INHIBITOR | Takeda Chemical Industries, Ltd. (JP) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016079-A2 | ALPHA-KETOAMIDE DERIVATIVES AS CATHEPSIN L INHIBITOR | TAKEDA CHEMICAL INDUSTRIES, LTD (JP) | 1996-05-30 | — | — | WO | disclosed |