Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 2/20 | 0.52 |
| ▸ | ANPEP | P15144 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 3/20 | 0.51 |
| ▸ | FCER2 | P06734 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18435374 | 0.85 | NPC1 (0.59) | ALDH1A1CA12CA1CA2CA3 | |
| SCHEMBL29511665 | 0.83 | MME (0.67) | MME | |
| SCHEMBL11780493 | 0.82 | CTSL (0.73) | CTSLANPEPMMP1FCER2 | |
| SCHEMBL8290604 | 0.82 | MMP1 (0.48) | CTSLMMP8ANPEPMMP1FCER2 | |
| SCHEMBL25627017 | 0.82 | MME (0.66) | MME | |
| SCHEMBL8119788 | 0.81 | CTSB (0.65) | CTSLMMP8MMP1FCER2 | |
| SCHEMBL14947756 | 0.80 | POLB (0.57) | MMP8ANPEPALDH1A1CA12CA1 | |
| SCHEMBL20804412 | 0.80 | POLB (0.57) | MMP8ANPEPALDH1A1CA12CA1 | |
| SCHEMBL22317109 | 0.80 | CTSS (0.52) | CTSLANPEPMME | |
| SCHEMBL2600864 | 0.80 | MMP8 (0.58) | MMP8ANPEPALDH1A1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977730-B1 | AMINO ACID DERIVATIVES INHIBITING EXTRACELLULAR MATRIX METALLOPROTEINASE AND TNF ALPHA RELEASE | CHIESI FARMA SPA (IT) | 2003-03-12 | — | — | EP | disclosed |
| US-6344457-B1 | RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, CORNEAL ULCERATION, PERIODONTITIS, GINGIVITIS OR TUMOROUS INVASION AND METASTATIC PROLIFERATION, ATHEROSCLEROSIS, AIDS, CHRONIC INFLAMMATORY DISEASES OF THE INTESTINE | CHIESI FARMACEUTICI S.P.A. (IT) | 2002-02-05 | — | — | US | disclosed |
| EP-0977730-A1 | AMINO ACID DERIVATIVES INHIBITING EXTRACELLULAR MATRIX METALLOPROTEINASE AND TNF ALPHA RELEASE | CHIESI FARMACEUTICI S.p.A. (IT) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998047863-A1 | AMINO ACID DERIVATIVES INHIBITING EXTRACELLULAR MATRIX METALLOPROTEINASE AND TNF ALPHA RELEASE | CHIESI FARMACEUTICI S.P.A. (IT) | 1998-10-29 | — | — | WO | disclosed |