SCHEMBL8769715

SCHEMBL8769715

CC(C)(C)c1ccc(S(=O)(=O)NC(=O)c2ccc([N+](=O)[O-])cc2)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FLT1 P17948 4/20 0.71
FLT4 P35916 4/20 0.71
KDR P35968 4/20 0.71
HDAC3 O15379 3/20 0.56
HDAC8 Q9BY41 3/20 0.56
HDAC6 Q9UBN7 3/20 0.56
HDAC11 Q96DB2 2/20 0.56
ALDH1A1 P00352 4/20 0.54
MAPT P10636 4/20 0.54
NPC1 O15118 2/20 0.54
LMNA P02545 2/20 0.54
RAB9A P51151 2/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
HPGD P15428 1/20 0.54
HTT P42858 1/20 0.54
CA1 P00915 1/20 0.54
CA2 P00918 1/20 0.54
MMP1 P03956 1/20 0.54
MMP2 P08253 1/20 0.54
MMP9 P14780 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23909567 0.90 FLT1 (0.85) FLT1FLT4KDRALDH1A1MAPT
SCHEMBL8627793 0.86 FLT1 (0.74) FLT1FLT4KDRALDH1A1MAPT
SCHEMBL8654939 0.84 FLT1 (0.76) FLT1FLT4KDRALDH1A1MAPT
SCHEMBL31061163 0.83 FLT1 (1.00) FLT1FLT4KDRALDH1A1CA1
SCHEMBL12201959 0.82 PTGS2 (0.66) FLT1FLT4KDRHDAC3HDAC8
SCHEMBL8661710 0.82 FLT1 (0.74) FLT1FLT4KDRALDH1A1MAPT
SCHEMBL26704182 0.81 LMNA (0.61) FLT1FLT4KDRHDAC3HDAC8
SCHEMBL9468106 0.79 FLT1 (0.64) FLT1FLT4KDRALDH1A1MAPT
SCHEMBL2684424 0.79 SRD5A2 (0.62) ALDH1A1MAPTNPC1LMNARAB9A
SCHEMBL7296723 0.78 RAB9A (0.71) HDAC3HDAC8HDAC6HDAC11ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-7224024-A None JP disclosed
EP-0659738-B1 N-(Carbonyl, carbonimidoyl, carbonothioyl) sulfonamide charge control agents and toners and developers EASTMAN KODAK CO (US) 1997-09-10 EP disclosed
US-5616797-A USED IN ELECTROPHOTOGRAPHY EASTMAN KODAK COMPANY (US) 1997-04-01 US disclosed
JP-H07224024-A SULFONAMIDE, DEVELOPER CONTAINING THE SAME AND DEVELOPING METHOD EASTMAN KODAK CO 1995-08-22 JP disclosed
EP-0659738-A1 N-(Carbonyl, carbonimidoyl, carbonothioyl) sulfonamide charge control agents and toners and developers EASTMAN KODAK COMPANY (US) 1995-06-28 EP disclosed
US-5405727-A Electrophotography EASTMAN KODAK COMPANY (US) 1995-04-11 US disclosed