Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | P4HB | P07237 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3393415 | 0.85 | TP53 (0.36) | CA2CA1GSK3BALDH1A1MAPT | |
| SCHEMBL572208 | 0.82 | CA2 (0.52) | CA2CA1GSK3BPARP15PARP10 | |
| SCHEMBL3205731 | 0.75 | CES2 (0.50) | CA2CA1GSK3BALDH1A1MAPT | |
| SCHEMBL811028 | 0.75 | ALDH1A1 (0.50) | GSK3BALDH1A1MAPTNPC1MEN1 | |
| SCHEMBL15540018 | 0.75 | TPMT (0.48) | CA2CA1GSK3BSLC6A3 | |
| SCHEMBL67959 | 0.75 | CES2 (0.50) | CA2CA1ALDH1A1MAPTNPC1 | |
| SCHEMBL28364182 | 0.75 | MAPT (0.42) | CA2CA1PARP10ALDH1A1MAPT | |
| SCHEMBL4247526 | 0.75 | CES2 (0.50) | CA2CA1GSK3BMAPTCA12 | |
| SCHEMBL84542 | 0.74 | CES1 (0.46) | CA2CA1ALDH1A1MAPTCA12 | |
| SCHEMBL11139683 | 0.74 | CES1 (0.46) | CA2CA1ALDH1A1MAPTCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0632019-B1 | Acylureas | ZENECA LTD (GB) | 1997-09-24 | — | — | EP | disclosed |
| US-5576334-A | ANTICOAGULANTS | ZENECA LIMITED (GB) | 1996-11-19 | — | — | US | disclosed |
| EP-0632019-A1 | Acylureas | ZENECA LIMITED (GB) | 1995-01-04 | — | — | EP | disclosed |