Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | TDO2 | P48775 | 1/20 | 0.49 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.49 |
| ▸ | CA2 | P00918 | 7/20 | 0.48 |
| ▸ | CA1 | P00915 | 6/20 | 0.48 |
| ▸ | CA12 | O43570 | 4/20 | 0.47 |
| ▸ | CA9 | Q16790 | 4/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27990769 | 0.85 | MAOA (0.68) | MAOAMAOBTDO2MAP2K4PTGS2 | |
| SCHEMBL6808976 | 0.84 | CA12 (0.54) | PTGS2PTGS1CA2CA1CA12 | |
| SCHEMBL6721496 | 0.83 | PTGS2 (0.66) | MAOAMAOBPTGS2PTGS1CA2 | |
| SCHEMBL6725866 | 0.79 | CA2 (0.57) | PTGS2PTGS1CA2CA1CA12 | |
| SCHEMBL6723983 | 0.79 | CA2 (0.57) | PTGS2PTGS1CA2CA1CA12 | |
| SCHEMBL6725794 | 0.78 | CA2 (0.68) | MAOAMAOBPTGS2PTGS1CA2 | |
| SCHEMBL6723830 | 0.77 | KIF11 (0.54) | PTGS2PTGS1CA2CA1CA12 | |
| SCHEMBL6726452 | 0.76 | CA9 (0.56) | PTGS2PTGS1CA2CA1CA12 | |
| SCHEMBL6724390 | 0.76 | CA2 (0.47) | PTGS2PTGS1CA2CA1CA12 | |
| SCHEMBL6726154 | 0.76 | PTGS2 (0.53) | MAOAMAOBPTGS2PTGS1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794942-A1 | SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996016934-A1 | SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-06-06 | — | — | WO | disclosed |