Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.56 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.52 |
| ▸ | GABRR2 | P28476 | 3/20 | 0.52 |
| ▸ | BLM | P54132 | 3/20 | 0.52 |
| ▸ | GABRR3 | A8MPY1 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.39 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL5874279 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3KMT2A | |
| Fumaric Acid SCHEMBL3965703 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3KMT2A | |
| Maleic Acid SCHEMBL30550381 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3KMT2A | |
| Fumaric Acid SCHEMBL27921137 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3KMT2A | |
| Fumaric Acid SCHEMBL1835362 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3KMT2A | |
| Maleic Acid SCHEMBL28650191 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3KMT2A | |
| Fumaric Acid SCHEMBL8771350 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3KMT2A | |
| Maleic Acid SCHEMBL18065037 | 0.87 | TSHR (0.64) | TSHRTP53EGLN1EGLN3KMT2A | |
| Fumaric Acid SCHEMBL2840791 | 0.87 | TSHR (0.64) | TSHRTP53EGLN1EGLN3KMT2A | |
| Maleic Acid SCHEMBL786851 | 0.87 | TSHR (0.64) | TSHRTP53EGLN1EGLN3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115849744-A | Preparation method of high-performance cement grinding aid | 信丰华轩建材有限公司 | 2023-03-28 | — | — | CN | claimed |
| CN-109476803-B | Amine compositions useful for making polyurethane foams | 赢创运营有限公司 | 2022-04-12 | — | — | CN | claimed |
| CN-106496400-B | A kind of phosphorous terpolymer and preparation method thereof | 上海三瑞高分子材料股份有限公司 | 2018-05-08 | — | — | CN | claimed |
| CN-115849744-A | Preparation method of high-performance cement grinding aid | 信丰华轩建材有限公司 | 2023-03-28 | — | — | CN | disclosed |
| CN-115612187-A | Antistatic and aging-resistant rubber and preparation method thereof | 江苏斯诺达科技有限公司 | 2023-01-17 | — | — | CN | disclosed |
| CN-115505072-A | Concrete modifier, preparation method thereof and concrete | 广西宝添环保材料有限公司 | 2022-12-23 | — | — | CN | disclosed |
| CN-114975939-A | Water-based cathode slurry, cathode pole piece and lithium ion battery | 武汉微美新材料科技有限公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-109476803-B | Amine compositions useful for making polyurethane foams | 赢创运营有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-107922564-B | Trimerization catalysts from sterically hindered salts and tertiary amines having isocyanate-reactive groups | 赢创运营有限公司 | 2021-10-19 | — | — | CN | disclosed |
| CN-110090206-A | Percutaneous absorption type preparation | 日东电工株式会社 | 2019-08-06 | — | — | CN | disclosed |
| WO-2019006331-A1 | COMPOSITIONS CONTAINING POLYCARBODIIMIDE COMPOUNDS | L'OREAL (FR) | 2019-01-03 | — | — | WO | disclosed |
| CN-104662707-A | Porous membrane separator for secondary batteries, method for producing same, and secondary battery | ZEON CORP | 2015-05-27 | — | — | CN | disclosed |
| CN-104364938-A | Method for producing porous membrane separator for lithium ion secondary batteries, and method for producing laminate for lithium ion secondary batteries | ZEON CORP | 2015-02-18 | — | — | CN | disclosed |
| US-20140212728-A1 | SLURRY FOR SECONDARY BATTERIES | ZEON CORPORATION (JP) | 2014-07-31 | — | — | US | disclosed |
| EP-1781717-B1 | COPOLYMER-CONTAINING CLEANING COMPOSITIONS | HENKEL AG & CO KGAA (DE) | 2012-11-07 | — | — | EP | disclosed |
| US-20100249249-A1 | Reduction of the Formation of Biofilm by Means of Multifunctional Copolymers | HENKEL AG & CO. KGAA (DE) | 2010-09-30 | — | — | US | disclosed |
| EP-1781717-A1 | COPOLYMER-CONTAINING CLEANING COMPOSITIONS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006005358-A1 | COPOLYMER-CONTAINING CLEANING COMPOSITIONS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2006-01-19 | — | — | WO | disclosed |
| EP-0798320-A2 | Ternary copolymer | NOF CORPORATION (JP) | 1997-10-01 | — | — | EP | disclosed |
| US-4529714-A | Using group 1a compound and reducing agent | BASF AKTIENGESELLSCHAFT (DE) | 1985-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249249-A1 | Reduction of the Formation of Biofilm by Means of Multifunctional Copolymers | PGLS, FGB, MUC1 | TSHR 3217/4885TP53 2781/4885EGLN1 2415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.