Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.34 |
| ▸ | HMGCR | P04035 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL453464 | 0.81 | — | — | |
| SCHEMBL4913156 | 0.81 | — | — | |
| SCHEMBL9685476 | 0.79 | TP53 (0.35) | TSHRCHRM1ADRA1ATP53TDP1 | |
| Citric Acid SCHEMBL6313398 | 0.77 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL3289690 | 0.77 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL2064710 | 0.75 | ALDH1A1 (0.68) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL653301 | 0.75 | ALDH1A1 (0.68) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL2064712 | 0.75 | ALDH1A1 (0.68) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL239487 | 0.75 | ALDH1A1 (0.68) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL27588805 | 0.75 | ALDH1A1 (0.68) | ALDH1A1KDM4ELMNAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0621507-B1 | Colour development composition and processing method using composition | CHUGAI SHASHIN YAKUHIN (JP) | 1997-10-08 | — | — | EP | disclosed |
| US-5466565-A | Color development composition and process | CHUGAI PHOTE CHEMICAL CO., LTD. (JP) | 1995-11-14 | — | — | US | disclosed |
| EP-0621507-A1 | Colour development composition and processing method using composition | CHUGAI PHOTO CHEMICAL CO. LTD. (JP) | 1994-10-26 | — | — | EP | disclosed |