Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.83 |
| ▸ | LMNA | P02545 | 1/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.83 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | GPR183 | P32249 | 1/20 | 0.32 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL9644059 | 0.96 | MEN1 (0.77) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL3726684 | 0.93 | MEN1 (0.71) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL7193959 | 0.92 | MEN1 (0.83) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL975 | 0.91 | — | — | |
| Tromethamine SCHEMBL17484 | 0.91 | MEN1 (1.00) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL3696191 | 0.91 | — | — | |
| Tromethamine SCHEMBL10528593 | 0.89 | MEN1 (0.67) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL1019777 | 0.88 | MEN1 (0.77) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL11744295 | 0.88 | MEN1 (0.77) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL6653331 | 0.88 | MEN1 (0.77) | MEN1LMNAKMT2ATNNC1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108085358-A | A kind of preparation method of canine parvovirus monoclonal antibody IgG2b-Fab segments | 保定冀中药业有限公司 | 2018-05-29 | — | — | CN | disclosed |