Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 9/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8772502 | 0.85 | ALOX5 (0.42) | HCRTR1HCRTR2ALOX5POLB | |
| SCHEMBL8772514 | 0.84 | HCRTR1 (0.41) | HCRTR1HCRTR2ALOX5APPPOLB | |
| SCHEMBL8772456 | 0.84 | NPC1 (0.44) | ALOX5POLBGAA | |
| SCHEMBL8442244 | 0.82 | HMOX1 (0.40) | POLBGAA | |
| SCHEMBL8772382 | 0.82 | HMOX1 (0.40) | POLBGAA | |
| SCHEMBL8443497 | 0.82 | HMOX1 (0.40) | POLBGAA | |
| SCHEMBL8443496 | 0.82 | HMOX1 (0.40) | POLBGAA | |
| SCHEMBL8102560 | 0.81 | HMOX1 (0.40) | ALOX5APPPOLB | |
| SCHEMBL8772457 | 0.81 | RAB9A (0.42) | HCRTR1HCRTR2ALOX5POLBGAA | |
| SCHEMBL8440303 | 0.79 | TP53 (0.45) | HCRTR1HCRTR2ALOX5POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | claimed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | claimed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |