Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.43 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.43 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.43 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.43 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8772387 | 0.91 | HMOX1 (0.40) | NPC1ALDH1A1POLBTDP1L3MBTL1 | |
| SCHEMBL8772456 | 0.87 | NPC1 (0.44) | TP53NPC1RAB9AF2RL1PLAAT3 | |
| SCHEMBL8772512 | 0.87 | PLAAT3 (0.40) | NPC1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL8772514 | 0.85 | HCRTR1 (0.41) | ALOX5POLBGAAHCRTR1HCRTR2 | |
| SCHEMBL8772447 | 0.82 | LMNA (0.45) | TP53NPC1RAB9APLAAT3PLAAT5 | |
| SCHEMBL8772384 | 0.82 | MAPT (0.42) | ALOX5MAPT | |
| SCHEMBL8443669 | 0.82 | HMOX1 (0.40) | NPC1ALDH1A1POLBGAATDP1 | |
| SCHEMBL8102560 | 0.81 | HMOX1 (0.40) | NPC1ALDH1A1ALOX5POLBTDP1 | |
| SCHEMBL8772457 | 0.80 | RAB9A (0.42) | TP53NPC1RAB9AALDH1A1ALOX5 | |
| SCHEMBL8104046 | 0.80 | HMOX1 (0.38) | NPC1ALDH1A1POLBGAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | claimed |
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |