Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 17/20 | 0.50 |
| ▸ | RARB | P10826 | 17/20 | 0.42 |
| ▸ | RARG | P13631 | 17/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | HNF4A | P41235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8772773 | 0.90 | RARA (0.39) | RARARARBRARGRXRA | |
| SCHEMBL8772633 | 0.84 | RARB (0.47) | RARARARBRARGRXRA | |
| SCHEMBL8772662 | 0.81 | RARB (0.42) | RARARARBRARGRXRA | |
| SCHEMBL8772796 | 0.80 | RARB (0.48) | RARARARBRARGRXRA | |
| SCHEMBL8772664 | 0.78 | RARB (0.40) | RARARARBRARGRXRA | |
| SCHEMBL8772741 | 0.78 | RARA (0.53) | RARARARBRARGHNF4A | |
| SCHEMBL8772736 | 0.77 | RARB (0.38) | RARARARBRARGRXRA | |
| SCHEMBL8772764 | 0.77 | RARB (0.33) | RARARARBRARGRXRA | |
| SCHEMBL8562392 | 0.76 | RARB (0.42) | RARARARBRARGRXRA | |
| SCHEMBL8772837 | 0.75 | RARA (0.35) | RARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800517-A1 | ACETYLENES DISUBSTITUTED WITH A 5 OR 8 SUBSTITUTED TETRAHYDRONAPHTHYL OR DIHYDRONAPHTHYL GROUP AND WITH AN ARYL OR HETEROARYL GROUPS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | Allergan (US) | 1997-10-15 | — | — | EP | disclosed |