Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 9/20 | 0.33 |
| ▸ | RARG | P13631 | 9/20 | 0.33 |
| ▸ | RARA | P10276 | 8/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | EIF4EBP1 | Q13541 | 2/20 | 0.32 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8772633 | 0.80 | RARB (0.47) | RARBRARGRARARXRA | |
| SCHEMBL8772773 | 0.78 | RARA (0.39) | RARBRARGRARARXRA | |
| SCHEMBL8772796 | 0.78 | RARB (0.48) | RARBRARGRARARXRA | |
| SCHEMBL8772752 | 0.77 | RARB (0.36) | RARBRARGRARARXRA | |
| SCHEMBL8772745 | 0.77 | RARA (0.50) | RARBRARGRARARXRA | |
| SCHEMBL8772762 | 0.76 | RARA (0.41) | RARBRARGRARA | |
| SCHEMBL8772664 | 0.76 | RARB (0.40) | RARBRARGRARARXRA | |
| SCHEMBL8772826 | 0.76 | RARB (0.39) | RARBRARGRARARXRA | |
| SCHEMBL8772662 | 0.75 | RARB (0.42) | RARBRARGRARARXRA | |
| SCHEMBL8666325 | 0.75 | RARB (0.34) | RARBRARGRARARXRABACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800517-A1 | ACETYLENES DISUBSTITUTED WITH A 5 OR 8 SUBSTITUTED TETRAHYDRONAPHTHYL OR DIHYDRONAPHTHYL GROUP AND WITH AN ARYL OR HETEROARYL GROUPS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | Allergan (US) | 1997-10-15 | — | — | EP | disclosed |