Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.38 |
| ▸ | CBFB | Q13951 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 3/20 | 0.35 |
| ▸ | CTSA | P10619 | 3/20 | 0.33 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.32 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.32 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8710227 | 0.82 | CYP3A4 (0.36) | — | |
| SCHEMBL8716474 | 0.74 | SCN8A (0.39) | CBFBPDE2ARUNX1ELANEFFAR1 | |
| SCHEMBL14406941 | 0.69 | CBFB (0.44) | TRPM8CBFBPDE2ARUNX1GPR139 | |
| SCHEMBL15023683 | 0.69 | CBFB (0.44) | TRPM8CBFBPDE2ARUNX1GPR139 | |
| SCHEMBL30903831 | 0.67 | GPR3 (0.42) | PDE2ASCN9A | |
| SCHEMBL19616709 | 0.67 | MAPT (0.43) | RUNX1 | |
| SCHEMBL29493403 | 0.67 | MAPT (0.43) | RUNX1 | |
| SCHEMBL21609588 | 0.67 | PRKDC (0.42) | TRPM8 | |
| SCHEMBL22208515 | 0.66 | SLC7A5 (0.43) | PDE2AFFAR1FFAR4SCN9A | |
| SCHEMBL31697025 | 0.66 | SLC7A5 (0.43) | PDE2AFFAR1FFAR4SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |