Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CBFB | Q13951 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.37 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8713091 | 0.86 | XDH (0.39) | SCN8ASCN10ARAB9ATLR7KDM4E | |
| SCHEMBL8709890 | 0.77 | RAB9A (0.37) | RAB9AKDM4EALDH1A1DHODH | |
| SCHEMBL8710186 | 0.77 | XDH (0.39) | RAB9AKDM4EALDH1A1MAPTLMNA | |
| SCHEMBL8772986 | 0.74 | TRPM8 (0.38) | SCN8ASCN10AROCK2CBFBRUNX1 | |
| SCHEMBL8713191 | 0.73 | MAPK8 (0.39) | RAB9AKDM4EALDH1A1DHODHMEN1 | |
| SCHEMBL8709579 | 0.73 | KDM4E (0.38) | RAB9AKDM4EALDH1A1MAPTDHODH | |
| SCHEMBL8712836 | 0.73 | MAPK8 (0.37) | RAB9AALDH1A1DHODHMEN1LMNA | |
| SCHEMBL8709365 | 0.72 | GRM4 (0.37) | RAB9ATLR7KDM4EALDH1A1MEN1 | |
| SCHEMBL8709054 | 0.71 | CYP3A4 (0.47) | KDM4EALDH1A1MAPT | |
| SCHEMBL15567520 | 0.71 | TRPM8 (0.51) | TLR7PDE2ATRPV1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |