Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 6/20 | 0.33 |
| ▸ | MAOA | P21397 | 4/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152348 | 0.87 | OPRM1 (0.38) | OPRM1OPRK1OPRL1MAOBMAOA | |
| SCHEMBL27698499 | 0.75 | OPRM1 (0.31) | OPRM1OPRK1OPRL1MAOBMAOA | |
| SCHEMBL10893354 | 0.75 | OPRM1 (0.34) | OPRM1OPRK1OPRL1MAOBMAOA | |
| SCHEMBL5906264 | 0.73 | TLR9 (0.40) | MAOBMAOAKCNH2MEN1CYP2C9 | |
| SCHEMBL13379626 | 0.73 | CA12 (0.48) | CHRM2KCNH2MEN1KMT2A | |
| SCHEMBL27823635 | 0.71 | ALDH1A1 (0.40) | OPRM1OPRK1OPRL1GRIN2DGRIN3B | |
| SCHEMBL7200658 | 0.71 | GAA (0.32) | MAOBMAOA | |
| SCHEMBL7863646 | 0.71 | — | — | |
| SCHEMBL6269999 | 0.71 | OPRL1 (0.34) | OPRM1OPRK1OPRL1MAOBMAOA | |
| SCHEMBL27906055 | 0.69 | MAOB (0.34) | OPRM1OPRK1OPRL1MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5674905-A | ADMINISTERING AS GASTRIN OR CHOLECYSTOKININ ANTAGONISTS | JAMES BLACK FOUNDATION LIMITED (GB) | 1997-10-07 | — | — | US | disclosed |
| EP-0655053-B1 | BICYCLOOCTANE AND BICYCLOHEPTANE DERIVATIVES | BLACK JAMES FOUNDATION (GB) | 1997-09-03 | — | — | EP | disclosed |
| EP-0655053-A1 | BICYCLOOCTANE AND BICYCLOHEPTANE DERIVATIVES. | BLACK JAMES FOUNDATION (GB) | 1995-05-31 | — | — | EP | disclosed |
| WO-1994000421-A1 | BICYCLOOCTANE AND BICYCLOHEPTANE DERIVATIVES | JAMES BLACK FOUNDATION LIMITED (GB) | 1994-01-06 | — | — | WO | disclosed |