Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | TTR | P02766 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 3/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | THRA | P10827 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGAV | P06756 | 1/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5063642 | 0.83 | MEN1 (0.47) | CYP3A4LMNAMEN1KMT2ATTR | |
| SCHEMBL5928053 | 0.83 | THRB (0.41) | CYP3A4LMNAMEN1KMT2ATTR | |
| SCHEMBL2010436 | 0.80 | LMNA (0.59) | CYP3A4LMNAMEN1KMT2ATTR | |
| SCHEMBL26794108 | 0.79 | ELANE (0.45) | CYP3A4LMNAMEN1KMT2ATTR | |
| SCHEMBL7094541 | 0.79 | CYP3A4 (0.55) | CYP3A4LMNAMEN1KMT2ATTR | |
| SCHEMBL7586397 | 0.79 | LMNA (0.50) | CYP3A4LMNAMEN1KMT2ATTR | |
| SCHEMBL3688841 | 0.77 | LMNA (0.50) | CYP3A4LMNAMEN1KMT2ATTR | |
| SCHEMBL23022578 | 0.77 | CYP3A4 (0.53) | CYP3A4LMNAMEN1KMT2ATTR | |
| SCHEMBL3688838 | 0.77 | KMT2A (0.47) | CYP3A4LMNAMEN1KMT2ATTR | |
| SCHEMBL12764452 | 0.77 | THRB (0.64) | CYP3A4LMNAMEN1KMT2ATTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802798-A1 | METHOD AND COMPOSITIONS FOR INCREASING THE SERUM HALF-LIFE OF PHARMACOLOGICALLY ACTIVE AGENTS | CHIRON CORPORATION (US) | 1997-10-29 | — | — | EP | disclosed |
| WO-1995022992-A1 | METHOD AND COMPOSITIONS FOR INCREASING THE SERUM HALF-LIFE OF PHARMACOLOGICALLY ACTIVE AGENTS | CHIRON CORPORATION (US) | 1995-08-31 | — | — | WO | disclosed |