Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.64 |
| ▸ | HRH1 | P35367 | 8/20 | 0.63 |
| ▸ | DRD1 | P21728 | 6/20 | 0.63 |
| ▸ | DRD5 | P21918 | 5/20 | 0.63 |
| ▸ | DRD4 | P21917 | 4/20 | 0.63 |
| ▸ | DRD3 | P35462 | 4/20 | 0.63 |
| ▸ | DRD2 | P14416 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8910594 | 0.91 | HRH1 (0.66) | HRH1DRD1DRD5DRD4DRD3 | |
| SCHEMBL8910600 | 0.91 | HRH1 (0.66) | HRH1DRD1DRD5DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL8909029 | 0.90 | HRH1 (0.65) | HRH1DRD1DRD5DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL8909022 | 0.90 | HRH1 (0.65) | HRH1DRD1DRD5DRD4DRD3 | |
| SCHEMBL8911288 | 0.86 | ALDH1A1 (0.61) | LTA4HHRH1DRD1DRD5DRD4 | |
| SCHEMBL8911278 | 0.86 | ALDH1A1 (0.61) | LTA4HHRH1DRD1DRD5DRD4 | |
| SCHEMBL11259795 | 0.85 | L3MBTL1 (0.54) | LTA4HHRH1DRD1DRD5DRD4 | |
| SCHEMBL7137384 | 0.85 | LTA4H (0.87) | LTA4H | |
| SCHEMBL11256970 | 0.85 | KDM4E (0.54) | LTA4HHRH1KMT2A | |
| SCHEMBL7135531 | 0.80 | LTA4H (0.78) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804427-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996011192-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-04-18 | — | — | WO | disclosed |