Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | LTA4H | P09960 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639322 | 0.82 | SMN1; SMN2 (0.62) | KMT2AMEN1LTA4HSMN1; SMN2ALDH1A1 | |
| SCHEMBL8773761 | 0.81 | MEN1 (0.54) | KMT2AMEN1LTA4HSMN1; SMN2ALDH1A1 | |
| SCHEMBL8635989 | 0.78 | SMN1; SMN2 (0.57) | KMT2AMEN1LTA4HSMN1; SMN2ALDH1A1 | |
| SCHEMBL7409264 | 0.77 | SMN1; SMN2 (0.68) | KMT2AMEN1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL28619865 | 0.77 | KMT2A (0.57) | KMT2AMEN1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL1437765 | 0.76 | ACKR3 (0.47) | KMT2ASMN1; SMN2ALDH1A1NPC1PKM | |
| SCHEMBL17842262 | 0.76 | RAB9A (0.75) | KMT2AMEN1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL8641254 | 0.75 | SMN1; SMN2 (0.56) | KMT2AMEN1LTA4HSMN1; SMN2ALDH1A1 | |
| SCHEMBL8640087 | 0.74 | SMN1; SMN2 (0.68) | KMT2AMEN1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL8773753 | 0.73 | MEN1 (0.46) | KMT2AMEN1LTA4HSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804427-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996011192-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-04-18 | — | — | WO | disclosed |