Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 11/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | DRD4 | P21917 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8773760 | 0.95 | LTA4H (0.65) | LTA4HL3MBTL1DRD4DRD2DRD3 | |
| SCHEMBL429857 | 0.86 | DRD4 (0.70) | DRD4GAADRD2DRD3 | |
| SCHEMBL9269886 | 0.85 | DRD4 (0.80) | LTA4HL3MBTL1DRD4GAADRD2 | |
| SCHEMBL20251326 | 0.81 | L3MBTL1 (0.81) | LTA4HL3MBTL1 | |
| SCHEMBL9330561 | 0.80 | DRD4 (0.74) | DRD4GAADRD2DRD3 | |
| SCHEMBL6468896 | 0.80 | LTA4H (0.67) | LTA4HL3MBTL1 | |
| SCHEMBL8672820 | 0.78 | LTA4H (0.74) | LTA4HL3MBTL1 | |
| SCHEMBL2091073 | 0.76 | LTA4H (0.60) | LTA4HL3MBTL1 | |
| SCHEMBL10829174 | 0.74 | LTA4H (0.68) | LTA4HL3MBTL1 | |
| SCHEMBL27836493 | 0.74 | LTA4H (0.63) | LTA4HL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804427-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996011192-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-04-18 | — | — | WO | disclosed |