Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.32 |
| ▸ | NQO1 | P15559 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774073 | 1.00 | CHRNB2 (0.38) | CHRNB2CHRNA2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8775006 | 0.91 | CHRNB2 (0.36) | CHRNB2CHRNA2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8775183 | 0.91 | RAB9A (0.40) | CHRNB2CHRNA2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8775176 | 0.91 | RAB9A (0.40) | CHRNB2CHRNA2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8775019 | 0.91 | CHRNB2 (0.36) | CHRNB2CHRNA2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL9158731 | 0.84 | CHRNB2 (0.37) | CHRNB2CHRNA2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL9158727 | 0.84 | CHRNB2 (0.37) | CHRNB2CHRNA2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8774579 | 0.83 | EGLN1 (0.33) | CACNA2D1EGLN1KDM4EALDH1A1MRGPRX4 | |
| SCHEMBL8774588 | 0.83 | EGLN1 (0.33) | CACNA2D1EGLN1KDM4EALDH1A1MRGPRX4 | |
| SCHEMBL8774420 | 0.83 | DHODH (0.40) | CACNA2D1KDM4EALDH1A1MRGPRX4DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |