Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | TACR2 | P21452 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774593 | 0.96 | FFAR1 (0.41) | HSD17B10TSHRMAPTRAB9AL3MBTL1 | |
| SCHEMBL8774695 | 0.90 | FFAR1 (0.43) | FFAR1ALDH1A1MCHR1 | |
| SCHEMBL8774556 | 0.84 | EGLN1 (0.47) | L3MBTL1FFAR1ALDH1A1LMNA | |
| SCHEMBL8774773 | 0.83 | ALDH1A1 (0.50) | HSD17B10TSHRRAB9AL3MBTL1KDM4E | |
| SCHEMBL8774397 | 0.83 | NPC1 (0.47) | HSD17B10RAB9AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL9161075 | 0.81 | FFAR1 (0.59) | HSD17B10TSHRKCNH2MAPTRAB9A | |
| SCHEMBL8774662 | 0.81 | RAB9A (0.46) | HSD17B10KCNH2MAPTRAB9AL3MBTL1 | |
| SCHEMBL9473645 | 0.80 | KCNH2 (0.58) | HSD17B10TSHRKCNH2KDM4EALDH1A1 | |
| SCHEMBL8774791 | 0.79 | SPHK1 (0.46) | MAPTRAB9AL3MBTL1FFAR1 | |
| SCHEMBL9472895 | 0.79 | KCNH2 (0.61) | HSD17B10TSHRKCNH2FFAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |