Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 9/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 2/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774750 | 0.96 | FFAR1 (0.38) | FFAR1CYP2A6ACACBEGLN1FFAR4 | |
| SCHEMBL8774295 | 0.88 | FFAR1 (0.44) | FFAR1ACACBFFAR4 | |
| SCHEMBL8774403 | 0.87 | FFAR1 (0.38) | FFAR1CYP2A6ACACBEGLN1FFAR4 | |
| SCHEMBL8774821 | 0.85 | FFAR1 (0.43) | FFAR1FFAR4TP53 | |
| SCHEMBL8774374 | 0.84 | FFAR1 (0.42) | FFAR1FFAR4LMNATP53 | |
| SCHEMBL8774994 | 0.84 | FFAR1 (0.42) | FFAR1ACACBFFAR4TP53 | |
| SCHEMBL8978844 | 0.83 | CYP2A6 (0.45) | FFAR1CYP2A6ACACBEGLN1FFAR4 | |
| SCHEMBL8774302 | 0.83 | HSD17B10 (0.43) | FFAR1FFAR4LMNATP53 | |
| SCHEMBL8774912 | 0.82 | TSHR (0.43) | FFAR1TP53 | |
| SCHEMBL8774805 | 0.82 | NQO1 (0.41) | FFAR1ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |