Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.32 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.32 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774977 | 1.00 | MRGPRX4 (0.35) | MRGPRX4PDGFRBPDGFRACACNA2D1CYP2C9 | |
| SCHEMBL8774223 | 0.91 | RAB9A (0.35) | MRGPRX4PDGFRBPDGFRACYP2C9ALDH1A1 | |
| SCHEMBL8774826 | 0.91 | RAB9A (0.40) | CYP2C9KCNH2RAB9A | |
| SCHEMBL8774229 | 0.91 | RAB9A (0.35) | MRGPRX4PDGFRBPDGFRACYP2C9ALDH1A1 | |
| SCHEMBL8774816 | 0.91 | RAB9A (0.40) | CYP2C9KCNH2RAB9A | |
| SCHEMBL8775232 | 0.89 | RAB9A (0.39) | MRGPRX4CYP2C9KCNH2LMNARAB9A | |
| SCHEMBL8775220 | 0.89 | RAB9A (0.39) | MRGPRX4CYP2C9KCNH2LMNARAB9A | |
| SCHEMBL9158454 | 0.84 | MAPT (0.38) | CACNA2D1CYP2C9ALDH1A1KDM4ECACNA1G | |
| SCHEMBL9158447 | 0.84 | MAPT (0.38) | CACNA2D1CYP2C9ALDH1A1KDM4ECACNA1G | |
| SCHEMBL8774420 | 0.83 | DHODH (0.40) | MRGPRX4CACNA2D1ALDH1A1KDM4EDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |