Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | RARB | P10826 | 4/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.40 |
| ▸ | RARG | P13631 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8775133 | 0.96 | HSD17B10 (0.49) | HSD17B10TSHRFFAR1RARBRARA | |
| SCHEMBL8774677 | 0.96 | FFAR1 (0.43) | HSD17B10TSHRFFAR1RAB9ASMN1; SMN2 | |
| SCHEMBL8774819 | 0.92 | FFAR1 (0.43) | HSD17B10TSHRFFAR1RARBRARA | |
| SCHEMBL8774719 | 0.91 | HSD17B10 (0.44) | HSD17B10TSHRFFAR1RARBRARA | |
| SCHEMBL8774897 | 0.88 | FFAR1 (0.45) | HSD17B10FFAR1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8774517 | 0.86 | EGLN1 (0.44) | FFAR1 | |
| SCHEMBL8774800 | 0.83 | RARB (0.49) | HSD17B10TSHRRARBRARARARG | |
| SCHEMBL8774086 | 0.83 | RARB (0.49) | HSD17B10TSHRRARBRARARARG | |
| SCHEMBL9158502 | 0.82 | HSD17B10 (0.47) | HSD17B10TSHRFFAR1RARBRARA | |
| SCHEMBL9510206 | 0.82 | TSHR (0.49) | HSD17B10TSHRRARBRARARARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |