Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 7/20 | 0.45 |
| ▸ | ACACB | O00763 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774819 | 0.96 | FFAR1 (0.43) | FFAR1ACACBNPC1TP53PKM | |
| SCHEMBL8774677 | 0.91 | FFAR1 (0.43) | FFAR1ACACBPKMRAB9ASMN1; SMN2 | |
| SCHEMBL8774719 | 0.89 | HSD17B10 (0.44) | FFAR1TP53RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL8774154 | 0.88 | EGLN1 (0.47) | FFAR1ACACBEGLN1GRM5 | |
| SCHEMBL8774460 | 0.88 | HSD17B10 (0.43) | FFAR1NPC1TP53PKMRAB9A | |
| SCHEMBL8775133 | 0.86 | HSD17B10 (0.49) | FFAR1NPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL8774517 | 0.84 | EGLN1 (0.44) | FFAR1ACACBEGLN1GRM5 | |
| SCHEMBL8774634 | 0.81 | KDM4E (0.43) | ACACBNPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL8774528 | 0.81 | ACACB (0.42) | ACACBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8774215 | 0.80 | ACACB (0.44) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |