Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | LPL | P06858 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9155797 | 0.83 | PIK3CD (0.48) | NISCHRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL10620525 | 0.82 | RAB9A (0.56) | NISCHRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL303902 | 0.79 | NPC1 (0.40) | RAB9ASMN1; SMN2NPC1TP53MAPT | |
| SCHEMBL8774882 | 0.79 | RAB9A (0.41) | NISCHRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL4802707 | 0.78 | LPL (0.54) | NISCHRAB9ANPC1MAPTGFER | |
| SCHEMBL7451380 | 0.77 | MAOB (0.59) | KDM4EALDH1A1GAAMCL1LPL | |
| SCHEMBL27433082 | 0.77 | IDO1 (0.45) | NISCHRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL10461717 | 0.77 | MCHR1 (0.48) | NISCHRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL11751515 | 0.77 | HSD17B10 (0.46) | NISCHRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL31434295 | 0.76 | MKNK1 (0.48) | RAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |