Sugi Predict

Sugi Predict / Compounds / SCHEMBL303902

SCHEMBL303902

SCHEMBL303902

CCCc1cnc(Cl)nc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 4/20 0.40
▸ RAB9A P51151 4/20 0.40
▸ KDM4E B2RXH2 4/20 0.40
▸ TP53 P04637 2/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.36
▸ PKM P14618 2/20 0.34
▸ HSD17B10 Q99714 1/20 0.34
▸ CA12 O43570 3/20 0.34
▸ CA1 P00915 3/20 0.34
▸ CA2 P00918 3/20 0.34
▸ CA6 P23280 3/20 0.34
▸ CA7 P43166 3/20 0.34
▸ CA13 Q8N1Q1 3/20 0.34
▸ PDK2 Q15119 1/20 0.33
▸ PDK4 Q16654 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33
▸ MEN1 O00255 2/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ ALDH1A1 P00352 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12760430 0.86 NFKB1 (0.46) NPC1RAB9AKDM4ETP53SMN1; SMN2
SCHEMBL2249764 0.84 RARB (0.46) NPC1RAB9AKDM4ETP53SMN1; SMN2
SCHEMBL8552636 0.82 RARB (0.49) NPC1RAB9AKDM4ETP53SMN1; SMN2
SCHEMBL4478012 0.82 RARB (0.49) NPC1RAB9AKDM4ETP53SMN1; SMN2
SCHEMBL7474682 0.82 RARB (0.49) NPC1RAB9AKDM4ETP53SMN1; SMN2
SCHEMBL8126315 0.82 RARB (0.49) NPC1RAB9AKDM4ETP53SMN1; SMN2
SCHEMBL304027 0.79 — —
SCHEMBL8774612 0.79 NISCH (0.41) NPC1RAB9AKDM4ETP53SMN1; SMN2
SCHEMBL12844629 0.77 NPC1 (0.41) NPC1RAB9AKDM4ETP53SMN1; SMN2
SCHEMBL423180 0.77 NPC1 (0.41) NPC1RAB9AKDM4ETP53SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 222 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240389588-A1 COMPOUNDS AND METHODS FOR TREATING NEMATODE INFECTIONS THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2024-11-28 — — US disclosed
CN-114945560-B GPR119 agonists 卡尔优普公司 2024-08-13 — — CN disclosed
US-12022832-B2 Compounds and methods for treating nematode infections THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2024-07-02 — — US disclosed
WO-2023229375-A1 HETEROCYCLIC COMPOUND AS DIACYLGLYCEROL KINASE INHIBITOR AND USE THEREOF 주식회사 엘지화학 2023-11-30 — — WO disclosed
CN-116669727-A Triazole-pyridinyl substituted azacyclohexylacetic acid compounds as LPA receptor antagonists 唯久生物有限公司 2023-08-29 — — CN disclosed
EP-4196220-A1 TRIAZOLE-PYRIDINYL SUBSTITUTED AZACYCLOHEXYL ACETIC ACID COMPOUNDS AS LPA RECEPTOR ANTAGONISTS Viva Star Biosciences Limited (HK) 2023-06-21 — — EP disclosed
WO-2023081923-A1 PLATELET-DERIVED GROWTH FACTOR RECEPTOR (PDGFR) ALPHA INHIBITORS AND USES THEREOF Frequency Therapeutics, Inc. (US) 2023-05-11 — — WO disclosed
US-20230061736-A1 GPR119 AGONISTS KALLYOPE, INC. 2023-03-02 — — US disclosed
US-11512065-B2 GPR119 agonists KALLYOPE, INC. (US) 2022-11-29 — — US disclosed
US-20220354117-A1 COMPOUNDS AND METHODS FOR TREATING NEMATODE INFECTIONS THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2022-11-10 — — US disclosed
US-6660738-B2 Such as (3R,5S)-1-pyrimidin-2-yl-5-(2,4,5-trifluoro-benzyloxymethyl)-pyrrolidine-3 -thiol trifluoro-acetate useful as inhibitors of metalloproteases for treating diseases associated with vasoconstriction HOFFMANN-LA ROCHE INC. 2003-12-09 — — US disclosed
US-20030186984-A1 Substituted cyclohexane derivatives HOFFMAN-LA ROCHE INC. 2003-10-02 — — US disclosed
CN-1443184-A Pyrimidine derivatives HOFFMANN LA ROCHE (CH) 2003-09-17 — — CN disclosed
WO-2003074495-A1 HPPARS ACTIVATORS SMITHKLINE BEECHAM CORPORATION (US) 2003-09-12 — — WO disclosed
WO-2003053933-A1 HETEROARYL-SUBSTITUTED AMINOCYCLOHEXANE DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 2003-07-03 — — WO disclosed
EP-1303507-A1 PYRIMIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2003-04-23 — — EP disclosed
US-20020055632-A1 Pyrrolidine derivatives F. HOFFMAN-LA ROCHE AG (CH) 2002-05-09 — — US disclosed
WO-2002006271-A1 PYRIMIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2002-01-24 — — WO disclosed
US-4871387-A Pyri(mi)dyl-oxy-and -thio-benzoic acid derivatives useful as herbicides and plant growth regulants BAYER AKTIENGESELLSCHAFT (DE) 1989-10-03 — — US disclosed
EP-0226837-A2 Pyri(mi)dyloxy and -thiobenzoic acid derivatives BAYER AG (DE) 1987-07-01 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12022832-B2 Compounds and methods for treating nematode infections HNMT, NISCH, HRH2 NPC1 385/4885RAB9A 2708/4885KDM4E 3946/4885
US-20030186984-A1 Substituted cyclohexane derivatives CYP51A1, LSS, CYP46A1 NPC1 73/4885RAB9A 2669/4885KDM4E 2077/4885
US-20220354117-A1 COMPOUNDS AND METHODS FOR TREATING NEMATODE INFECTIONS HNMT, NISCH, HRH2 NPC1 385/4885RAB9A 2708/4885KDM4E 3946/4885
US-11512065-B2 GPR119 agonists GPR119, GLP1R, GCGR NPC1 1116/4885RAB9A 1074/4885KDM4E 1450/4885
US-20230061736-A1 GPR119 AGONISTS GPR119, GLP1R, GCGR NPC1 1116/4885RAB9A 1074/4885KDM4E 1450/4885
US-20020055632-A1 Pyrrolidine derivatives PREP, PEPD, MMP3 NPC1 2743/4885RAB9A 2939/4885KDM4E 1357/4885
US-20240389588-A1 COMPOUNDS AND METHODS FOR TREATING NEMATODE INFECTIONS HNMT, NISCH, HRH2 NPC1 385/4885RAB9A 2708/4885KDM4E 3946/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.