Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8760983 | 0.72 | CYP17A1 (0.35) | OPRD1CYP17A1CYP2D6CHRM2HTR1A | |
| SCHEMBL18762175 | 0.69 | SIGMAR1 (0.43) | OPRD1SIGMAR1CYP2D6CHRM2HTR1A | |
| SCHEMBL2579537 | 0.66 | CYP2D6 (0.48) | OPRD1CYP17A1SIGMAR1CYP2D6CHRM2 | |
| SCHEMBL11010784 | 0.66 | GRM2 (0.41) | OPRD1KMT2A | |
| SCHEMBL10839513 | 0.66 | CYP17A1 (0.35) | OPRD1CYP17A1CYP2D6CHRM2ADRA2A | |
| SCHEMBL9283446 | 0.64 | CYP17A1 (0.38) | OPRD1CYP17A1CYP2D6KCNH2KMT2A | |
| SCHEMBL3294321 | 0.64 | CYP2D6 (0.55) | OPRD1CYP17A1CYP2D6CHRM2ADRA2A | |
| SCHEMBL986928 | 0.64 | CYP2D6 (0.59) | CYP2D6CHRM2HTR1AADRA2ACHRM1 | |
| SCHEMBL29078122 | 0.63 | CYP17A1 (0.51) | CYP17A1KMT2A | |
| SCHEMBL6837651 | 0.62 | CYP1A2 (0.57) | CYP2D6KCNH2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0578185-B1 | 1-aza-2-silacyclobutane compounds and method for their preparation | DOW CORNING KK (JP) | 1997-09-17 | — | — | EP | claimed |
| US-5281737-A | 1-aza-2-silacyclobutane compounds and method for their preparation | DOW CORNING JAPAN, LTD. (JP) | 1994-01-25 | — | — | US | claimed |
| EP-0578185-A1 | 1-AZA-2-silacyclobutane compounds and method for their preparation | DOW CORNING JAPAN, LTD. (JP) | 1994-01-12 | — | — | EP | claimed |
| EP-0578185-B1 | 1-aza-2-silacyclobutane compounds and method for their preparation | DOW CORNING KK (JP) | 1997-09-17 | — | — | EP | disclosed |
| US-5281737-A | 1-aza-2-silacyclobutane compounds and method for their preparation | DOW CORNING JAPAN, LTD. (JP) | 1994-01-25 | — | — | US | disclosed |
| EP-0578185-A1 | 1-AZA-2-silacyclobutane compounds and method for their preparation | DOW CORNING JAPAN, LTD. (JP) | 1994-01-12 | — | — | EP | disclosed |