Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
| ▸ | DRD1 | P21728 | 2/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774648 | 0.72 | OPRD1 (0.37) | CYP17A1CYP2D6KCNH2OPRD1CHRM2 | |
| SCHEMBL3294321 | 0.71 | CYP2D6 (0.55) | CYP17A1CYP2D6KCNH2CYP1A2CYP3A4 | |
| SCHEMBL2579537 | 0.70 | CYP2D6 (0.48) | CYP17A1CYP2D6KCNH2CYP1A2CYP3A4 | |
| SCHEMBL11136769 | 0.69 | CYP1A2 (0.57) | CYP2D6KCNH2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6837651 | 0.69 | CYP1A2 (0.57) | CYP2D6KCNH2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6838012 | 0.69 | CYP1A2 (0.57) | CYP2D6KCNH2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL30518149 | 0.69 | CYP1A2 (0.57) | CYP2D6KCNH2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6837652 | 0.69 | CYP1A2 (0.57) | CYP2D6KCNH2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL2361182 | 0.69 | CYP1A2 (0.57) | CYP2D6KCNH2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL986928 | 0.67 | CYP2D6 (0.59) | CYP2D6KCNH2CYP3A4CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0578186-B1 | Method for the preparation of 1-aza-2-silacyclopentane compounds | DOW CORNING KK (JP) | 1997-06-04 | — | — | EP | disclosed |
| US-5281736-A | Method for the preparation of 1-aza-2-silacyclopentane compounds | DOW CORNING JAPAN, LTD. (JP) | 1994-01-25 | — | — | US | disclosed |
| EP-0578186-A1 | Method for the preparation of 1-AZA-2-silacyclopentane compounds | DOW CORNING JAPAN, LTD. (JP) | 1994-01-12 | — | — | EP | disclosed |