Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.31 |
| ▸ | RARB | P10826 | 2/20 | 0.31 |
| ▸ | RARA | P10276 | 1/20 | 0.31 |
| ▸ | RARG | P13631 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774698 | 1.00 | GAA (0.33) | GAAMAPTPDE5AGRIN2BGRIN1 | |
| SCHEMBL8774704 | 0.99 | PDE5A (0.33) | GAAMAPTPDE5AGRIN2BGRIN1 | |
| SCHEMBL8775100 | 0.96 | ESR2 (0.33) | GAAMAPTPDE5AGRIN2BGRIN1 | |
| SCHEMBL8774394 | 0.91 | GRIN2B (0.33) | GRIN2BGRIN1PTGS2GPR55 | |
| SCHEMBL8774169 | 0.86 | GRIN2B (0.36) | GRIN2BGRIN1PTGS2GPR55 | |
| SCHEMBL9156816 | 0.85 | GAA (0.35) | GAAMAPTPTGS2 | |
| SCHEMBL9158940 | 0.85 | GAA (0.35) | GAAMAPTPTGS2 | |
| SCHEMBL9157491 | 0.84 | PTGS2 (0.35) | GAAMAPTPTGS2 | |
| SCHEMBL8774193 | 0.83 | SLC6A2 (0.34) | GAAMAPTPTGS2 | |
| SCHEMBL8774253 | 0.83 | SLC6A2 (0.34) | GAAMAPTPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |