Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774333 | 0.98 | GCGR (0.40) | GCGRMAPK14SMN1; SMN2TP53TAAR1 | |
| SCHEMBL8774928 | 0.87 | NPC1 (0.40) | SMN1; SMN2TP53TAAR1RAB9ANPC1 | |
| SCHEMBL8774599 | 0.85 | NPC1 (0.41) | SMN1; SMN2TP53RAB9ANPC1MAPT | |
| SCHEMBL8774685 | 0.84 | RARB (0.45) | SMN1; SMN2TP53RAB9ANPC1ALDH1A1 | |
| SCHEMBL8774744 | 0.83 | GCGR (0.38) | GCGRMAPK14SMN1; SMN2TP53TAAR1 | |
| SCHEMBL8774890 | 0.83 | RARB (0.50) | SMN1; SMN2RAB9AGAAALDH1A1MAPT | |
| SCHEMBL8774855 | 0.82 | RARB (0.46) | SMN1; SMN2TP53RAB9ANPC1ALDH1A1 | |
| SCHEMBL8774472 | 0.81 | RARB (0.51) | MAPK14SMN1; SMN2TP53LMNARAB9A | |
| SCHEMBL15471664 | 0.79 | TAAR1 (0.43) | GCGRMAPK14TP53TAAR1LMNA | |
| SCHEMBL8774097 | 0.79 | FFAR4 (0.45) | SMN1; SMN2TP53LMNARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |