Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 5/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774007 | 0.88 | RAB9A (0.42) | MAPTNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL8774419 | 0.85 | RARB (0.43) | GCGRMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8774333 | 0.85 | GCGR (0.40) | GCGRMAPK14MAPTNPC1RAB9A | |
| SCHEMBL8775053 | 0.84 | RARB (0.48) | MAPTMEN1KMT2ARAB9AGAA | |
| SCHEMBL8774763 | 0.83 | GCGR (0.40) | GCGRMAPK14MAPTNPC1RAB9A | |
| SCHEMBL8774679 | 0.83 | RARB (0.50) | MAPK14MAPTMEN1KMT2ARAB9A | |
| SCHEMBL8775158 | 0.78 | GPR84 (0.34) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL8775154 | 0.78 | GPR84 (0.34) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL8774629 | 0.78 | GPR84 (0.34) | — | |
| SCHEMBL15471664 | 0.77 | TAAR1 (0.43) | GCGRMAPK14TP53METAP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |