Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 8/20 | 0.45 |
| ▸ | RARA | P10276 | 1/20 | 0.45 |
| ▸ | RARG | P13631 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | MPL | P40238 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CTRC | Q99895 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774855 | 0.98 | RARB (0.46) | RARBRARARARGTSHRHSD17B10 | |
| SCHEMBL8774890 | 0.95 | RARB (0.50) | RARBRARARARGTSHRHSD17B10 | |
| SCHEMBL8774472 | 0.94 | RARB (0.51) | RARBRARARARGTSHRHSD17B10 | |
| SCHEMBL8774928 | 0.91 | NPC1 (0.40) | RARBRARARARGTSHRHSD17B10 | |
| SCHEMBL8774599 | 0.89 | NPC1 (0.41) | RARBRARARARGHSD17B10NPC1 | |
| SCHEMBL8774419 | 0.85 | RARB (0.43) | RARBRARARARGTSHRNPC1 | |
| SCHEMBL8774763 | 0.84 | GCGR (0.40) | NPC1RAB9ASMN1; SMN2TP53NISCH | |
| SCHEMBL8774250 | 0.84 | RARB (0.44) | RARBRARARARGTSHRHSD17B10 | |
| SCHEMBL8774333 | 0.82 | GCGR (0.40) | NPC1RAB9ASMN1; SMN2TP53NISCH | |
| SCHEMBL8774107 | 0.82 | GPR84 (0.38) | RARBRARARARGNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |