Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RARB | P10826 | 8/20 | 0.47 |
| ▸ | RARA | P10276 | 2/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774222 | 1.00 | MAPT (0.51) | MAPTRAB9ASMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL8774115 | 0.98 | RAB9A (0.49) | MAPTRAB9ASMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL8774724 | 0.94 | AKR1C2 (0.50) | MAPTRAB9ASMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL8774882 | 0.88 | RAB9A (0.41) | MAPTRAB9ASMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL8774251 | 0.86 | RARB (0.53) | MAPTRAB9ASMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL8774831 | 0.86 | RARB (0.53) | MAPTRAB9ASMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL8774917 | 0.85 | RARB (0.51) | MAPTRAB9ASMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL8774263 | 0.84 | MAPT (0.37) | MAPTRAB9ASMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL8774209 | 0.84 | MAPT (0.37) | MAPTRAB9ASMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL8774260 | 0.84 | MAPT (0.37) | MAPTRAB9ASMN1; SMN2HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |