Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 1/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | CTRC | Q99895 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774115 | 0.95 | RAB9A (0.49) | AKR1C2AKR1C1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8774222 | 0.94 | MAPT (0.51) | AKR1C2AKR1C1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8774963 | 0.94 | MAPT (0.51) | AKR1C2AKR1C1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8774882 | 0.90 | RAB9A (0.41) | AKR1C2AKR1C1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8774995 | 0.86 | RARB (0.46) | AKR1C2AKR1C1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8774663 | 0.84 | SMN1; SMN2 (0.45) | AKR1C2AKR1C1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8774839 | 0.83 | EGLN1 (0.45) | RAB9ASMN1; SMN2NPC1L3MBTL1MAPK1 | |
| SCHEMBL8774323 | 0.83 | GPR84 (0.38) | AKR1C2AKR1C1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8774328 | 0.83 | GPR84 (0.38) | AKR1C2AKR1C1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8774201 | 0.82 | AKR1C2 (0.36) | AKR1C2AKR1C1RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |