Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.55 |
| ▸ | MAOB | P27338 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5485070 | 0.92 | TAAR1 (0.46) | TAAR1MAOBCYP2A6AOC3 | |
| SCHEMBL12190393 | 0.86 | TAAR1 (0.61) | TAAR1MAOBKDM4EATMCYP1A2 | |
| SCHEMBL139733 | 0.84 | TAAR1 (0.43) | TAAR1MAOBKDM4ELMNAAOC3 | |
| Ethylenediamine SCHEMBL17417251 | 0.83 | HTR2A (0.50) | TAAR1CYP2A6HTR2A | |
| SCHEMBL9660429 | 0.82 | TAAR1 (0.45) | TAAR1MAOBKDM4EATM | |
| SCHEMBL4291669 | 0.82 | TAAR1 (0.41) | TAAR1MAOBKDM4EATMAOC3 | |
| SCHEMBL8955746 | 0.79 | CYP19A1 (0.53) | TAAR1MAOBKDM4EATMTSHR | |
| SCHEMBL27094924 | 0.78 | MAOB (0.48) | TAAR1MAOBAOC3 | |
| SCHEMBL8775075 | 0.77 | SIGMAR1 (0.46) | TAAR1MAOBMEN1KMT2A | |
| SCHEMBL11648990 | 0.76 | TAAR1 (0.46) | TAAR1MAOBCYP1A2CYP2A6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462570-B1 | Magnetic recording medium | MATSUSHITA ELECTRIC INDUSTRIAL CO LTD (JP) | 1997-11-19 | — | — | EP | claimed |
| US-5219652-A | Back coat layer including spherical particles which have been surface-treated for lubricity | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1993-06-15 | — | — | US | claimed |