SCHEMBL8775830

SCHEMBL8775830

Fc1ccc(C2CNCCO2)cc1F

nearest known ligand 0.62

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 1/20 0.56
DRD3 P35462 1/20 0.56
HTR1A P08908 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27885240 0.87 DRD2 (0.54) DRD2DRD3HTR1A
SCHEMBL26251626 0.86
SCHEMBL16464076 0.86 SLC6A2 (0.53) DRD2DRD3HTR1A
SCHEMBL12695907 0.86 DRD2 (0.52) DRD2DRD3HTR1A
SCHEMBL14151352 0.86 DRD2 (0.52) DRD2DRD3HTR1A
SCHEMBL14151320 0.86 DRD2 (0.52) DRD2DRD3HTR1A
SCHEMBL16464078 0.86 SLC6A2 (0.53) DRD2DRD3HTR1A
SCHEMBL16465017 0.86
SCHEMBL16464576 0.83 HTR1A (0.60) DRD2DRD3HTR1A
SCHEMBL16464578 0.83 HTR1A (0.60) DRD2DRD3HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025133334-A1 NOVEL VDAC1 INHIBITORS ABARCEO PHARMA AB (SE) 2025-06-26 WO disclosed
CN-117402124-A Aryl sulfonamide compound and anti-influenza application thereof 中国医学科学院医药生物技术研究所 2024-01-16 CN disclosed
US-9353096-B2 Substituted phenylcarbamate compounds HOFFMANN-LA ROCHE INC. (US) 2016-05-31 US disclosed
EP-2906544-A1 SUBSTITUTED PHENYLCARBAMATE COMPOUNDS F. Hoffmann-La Roche AG (CH) 2015-08-19 EP disclosed
US-20150218144-A1 SUBSTITUTED PHENYLCARBAMATE COMPOUNDS HOFFMANN-LA ROCHE INC. (US) 2015-08-06 US disclosed
CN-104703973-A Substituted phenyl carbamate compounds HOFFMANN LA ROCHE 2015-06-10 CN disclosed
WO-2014056958-A1 SUBSTITUTED PHENYLCARBAMATE COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2014-04-17 WO disclosed
EP-0807111-A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME SANOFI (FR) 1997-11-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150218144-A1 SUBSTITUTED PHENYLCARBAMATE COMPOUNDS TRPA1, TRPV1, TRPV3 DRD2 1425/4885DRD3 1226/4885HTR1A 331/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.