Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 9/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 9/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 9/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
| ▸ | ALPG | P10696 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12714377 | 0.78 | APP (0.51) | ESR1ESR2CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL12952317 | 0.77 | SNCA (0.44) | CSNK2A2CSNK2BCSNK2A1ALDH1A1POLB | |
| SCHEMBL14885544 | 0.71 | TERT (0.35) | ESR2 | |
| SCHEMBL327849 | 0.69 | APP (0.63) | CSNK2A2CSNK2BCSNK2A1ALDH1A1POLB | |
| SCHEMBL17696461 | 0.65 | HSD17B3 (0.42) | CSNK2A2CSNK2BCSNK2A1ALDH1A1POLB | |
| SCHEMBL12714456 | 0.64 | SNCA (0.47) | CSNK2A2CSNK2BCSNK2A1ALDH1A1POLB | |
| SCHEMBL18924217 | 0.63 | KDM4E (0.43) | ALDH1A1POLBMAPTRAB9AKDM4E | |
| SCHEMBL4015074 | 0.63 | SLC6A3 (0.35) | ALDH1A1 | |
| SCHEMBL565580 | 0.62 | MCL1 (0.55) | ALDH1A1POLBMAPTKDM4EMEN1 | |
| SCHEMBL29391372 | 0.62 | MCL1 (0.55) | ALDH1A1POLBMAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9284541-B2 | Methods and compositions for protein labeling using lipoic acid ligases | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2016-03-15 | — | — | US | disclosed |
| US-20120129159-A1 | METHODS AND COMPOSITIONS FOR PROTEIN LABELING USING LIPOIC ACID LIGASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-05-24 | — | — | US | disclosed |
| US-20120129159-A1 | METHODS AND COMPOSITIONS FOR PROTEIN LABELING USING LIPOIC ACID LIGASES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129159-A1 | METHODS AND COMPOSITIONS FOR PROTEIN LABELING USING LIPOIC ACID LIGASES | LARS1, ACSL5, RARS1 | CSNK2A2 3413/4885CSNK2B 3590/4885CSNK2A1 3255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.