SCHEMBL8776592

SCHEMBL8776592

O=C1C=C(c2ccc(C=Cc3ccc(C4=CC(=O)NC4=O)cc3)cc2)C(=O)N1

nearest known ligand 0.34

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAOB P27338 6/20 0.34
MAOA P21397 3/20 0.34
SIRT2 Q8IXJ6 1/20 0.32
SIRT1 Q96EB6 1/20 0.32
SIRT3 Q9NTG7 1/20 0.32
SIRT5 Q9NXA8 1/20 0.32
PIM1 P11309 1/20 0.31
PIM2 Q9P1W9 1/20 0.31
METAP1 P53582 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL448198 0.87 BACE1 (0.32)
SCHEMBL16668754 0.85 HSD17B3 (0.34) MAOBMAOA
SCHEMBL9104697 0.85 ALDH1A1 (0.41) SIRT2SIRT1SIRT3SIRT5
SCHEMBL2712453 0.79 HAO1 (0.42) MAOBMAOAPIM1PIM2
SCHEMBL3795697 0.78 CYP3A4 (0.40)
SCHEMBL28438497 0.78 HSD17B3 (0.47) MAOBMAOASIRT2SIRT1SIRT3
SCHEMBL1232781 0.78 RECQL (0.41) PIM1PIM2
SCHEMBL27812998 0.78 TGM2 (0.33)
SCHEMBL552048 0.78 MGAM (0.43) METAP1
SCHEMBL1087322 0.78 ALDH1A1 (0.42) MAOBMAOAPIM1PIM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5494948-A OBTAINED BY HEATING AND MELTING MIXTURE CONTAINING CRYSTALLINE POLYPROPYLENE, MICA TREATED WITH ORGANOSILANE COMPOUND, BISMALEIMIDE COMPOUND, ORGANIC PEROXIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-02-27 US claimed
EP-0645427-B1 Mica-reinforced propylene resin composition SUMITOMO CHEMICAL CO (JP) 1997-12-03 EP disclosed
US-5494948-A OBTAINED BY HEATING AND MELTING MIXTURE CONTAINING CRYSTALLINE POLYPROPYLENE, MICA TREATED WITH ORGANOSILANE COMPOUND, BISMALEIMIDE COMPOUND, ORGANIC PEROXIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-02-27 US disclosed
EP-0645427-A1 Mica-reinforced propylene resin composition SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1995-03-29 EP disclosed