Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 9/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3605491 | 0.76 | ALDH1A1 (0.55) | KDM4EMAPTCXCR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8776813 | 0.72 | TSHR (0.61) | KDM4EMAPTCXCR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL15897470 | 0.71 | MAPT (0.50) | KDM4EMAPTCXCR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL16297352 | 0.70 | TP53 (0.46) | KDM4EMAPTCXCR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8776755 | 0.69 | TSHR (0.58) | KDM4EMAPTCXCR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL30697697 | 0.68 | CXCR2 (0.38) | KDM4EMAPTCXCR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL26119745 | 0.68 | CXCR2 (0.38) | KDM4EMAPTCXCR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL7051248 | 0.68 | LRRK2 (0.41) | KDM4EMAPTALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL1846079 | 0.68 | TSHR (0.44) | KDM4EMAPTALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL2965820 | 0.67 | ALDH1A1 (0.49) | KDM4EMAPTALDH1A1SMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |