Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | HPGD | P15428 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.53 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.53 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | NPY1R | P25929 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3605491 | 0.86 | ALDH1A1 (0.55) | TSHRKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL30511865 | 0.83 | TSHR (0.62) | TSHRKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL31371177 | 0.78 | ADORA1 (0.53) | TSHRKDM4EALDH1A1HPGDMAPT | |
| Tasuldine SCHEMBL1813288 | 0.74 | HSD17B10 (0.66) | KDM4ELMNAHSD17B10MAPK1CYP1A2 | |
| SCHEMBL8776779 | 0.72 | KDM4E (0.46) | TSHRKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL15897470 | 0.72 | MAPT (0.50) | TSHRKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL16297352 | 0.71 | TP53 (0.46) | TSHRKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL15693240 | 0.70 | ALDH1A1 (0.57) | TSHRKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL8776755 | 0.70 | TSHR (0.58) | TSHRKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL25432423 | 0.69 | ADORA1 (0.56) | TSHRKDM4EALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |