SCHEMBL877685

SCHEMBL877685

O=C(CN1CCOCC1)Nc1cccc(-c2nc(Nc3ccc4c(cnn4C(=O)O)c3)c3ccccc3n2)c1

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
JAK3 P52333 2/20 0.53
ROCK2 O75116 4/20 0.52
ROCK1 Q13464 1/20 0.49
EGFR P00533 2/20 0.47
MEN1 O00255 4/20 0.47
KMT2A Q03164 4/20 0.47
MAPT P10636 3/20 0.47
LMNA P02545 2/20 0.47
MAPK1 P28482 3/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
KDM4E B2RXH2 1/20 0.46
ABCG2 Q9UNQ0 1/20 0.46
MAP4K4 O95819 1/20 0.45
KDM1A O60341 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.44
JAK2 O60674 1/20 0.44
TP53 P04637 1/20 0.44
ALDH1A1 P00352 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL877930 0.90 ROCK2 (0.51) JAK3ROCK2ROCK1EGFRMEN1
SCHEMBL3795144 0.88 ROCK2 (0.61) JAK3ROCK2ROCK1EGFRMAPT
SCHEMBL1723523 0.85 ROCK2 (0.66) JAK3ROCK2ROCK1EGFRMAPT
SCHEMBL1726310 0.85 ROCK2 (0.66) ROCK2ROCK1EGFRMAPTALDH1A1
SCHEMBL876581 0.84 ROCK2 (0.70) JAK3ROCK2ROCK1EGFR
SCHEMBL3790306 0.84 ROCK2 (0.77) ROCK2ROCK1EGFRMAPTALDH1A1
SCHEMBL3798006 0.82 EGFR (0.46) JAK3ROCK2ROCK1EGFRMEN1
SCHEMBL877390 0.81 MEN1 (0.50) EGFRMEN1KMT2AMAPTLMNA
SCHEMBL4784466 0.81 ABCG2 (0.50) ROCK2ROCK1EGFRMEN1KMT2A
SCHEMBL1726552 0.80 ABCG2 (0.53) ROCK2MEN1KMT2AMAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012040499-A2 METABOLIC INHIBITORS SURFACE LOGIX, INC. (US) 2012-03-29 WO disclosed
WO-2008054599-A2 RHO KINASE INHIBITORS SURFACE LOGIX, INC. (US) 2008-05-08 WO disclosed
EP-1865958-A2 PHARMACOKINETICALLY IMPROVED COMPOUNDS Surface Logix, Inc. (US) 2007-12-19 EP disclosed
WO-2006105081-A2 PHARMACOKINETICALLY IMPROVED COMPOUNDS SURFACE LOGIX, INC. (US) 2006-10-05 WO disclosed