Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9468333 | 0.82 | ATM (0.66) | ATMKDM4ESTAT3CYP19A1AOC3 | |
| SCHEMBL6778497 | 0.79 | STAT3 (0.58) | ATMKDM4ESTAT3CYP19A1AOC3 | |
| SCHEMBL2759507 | 0.78 | ATM (0.63) | ATMKDM4ESTAT3CYP19A1AOC3 | |
| SCHEMBL26831762 | 0.78 | SIGMAR1 (0.50) | ATMKDM4ESTAT3POLBCA2 | |
| SCHEMBL10776111 | 0.78 | STAT3 (0.53) | ATMKDM4ESTAT3CYP19A1AOC3 | |
| SCHEMBL16973633 | 0.77 | ATM (0.59) | ATMKDM4ESTAT3CYP19A1AOC3 | |
| SCHEMBL14747869 | 0.77 | HTR1A (0.41) | ATMKDM4ESTAT3CYP1A2CYP3A4 | |
| SCHEMBL4991094 | 0.76 | LDHA (0.47) | ATMKDM4ESTAT3CA2KMT2A | |
| SCHEMBL2468726 | 0.76 | ATM (0.79) | ATMKDM4ECYP19A1AOC3POLB | |
| SCHEMBL3872175 | 0.76 | PPARG (0.62) | ATMKDM4ECYP19A1POLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800514-A1 | SUBSTITUTED IMIDES AS TNF INHIBITORS | CELGENE CORPORATION (US) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996020926-A1 | SUBSTITUTED IMIDES AS TNF INHIBITORS | CELGENE CORPORATION (US) | 1996-07-11 | — | — | WO | disclosed |